OVA1 Improves Ovarian Cancer Detection Over CA 125 Blood Test and Clinical Assessment

Second study in Obstetrics & Gynecology showcases OVA1’s role in evaluating women with an ovarian mass

MADISON, NJ AND AUSTIN, TX, MAY 24, 2011
(NASDAQ: VRML)

A paper published in the June issue of Obstetrics & Gynecology demonstrated that adding OVA1 to a physician's preoperative assessment of a woman's ovarian mass would identify more ovarian cancers than a physician's preoperative assessment alone. The study is the second published online this month in the journal, which is the official publication of the American College of Obstetricians and Gynecologists (ACOG), to show OVA1's value over the CA 125 test in evaluating women for the likelihood of ovarian cancer prior to surgery.

OVA1 Blood Test Detects Ovarian Cancer More Accurately Than Medically Accepted CA 125 Method for Evaluating Women with Ovarian Mass

Obstetrics & Gynecology study also considers OVA1’s place in future surgical referral guidelines

MADISON, NJ AND AUSTIN, TX, MAY 12, 2011
(NASDAQ: VRML)

A study published online ahead of print in the June 2011 edition of Obstetrics & Gynecology demonstrated that American College of Obstetrics and Gynecology (ACOG) guidelines for determining the likelihood that an ovarian mass is cancerous prior to surgery would accurately identify more women with ovarian cancer if the OVA1 blood test were used in place of the currently recommended CA 125 blood test. The study builds on prior research that shows accurate assessment of an ovarian mass for cancer prior to surgery can affect both treatment decisions and health outcomes for women with ovarian cancer.

OVA1 is the first test cleared by the U.S. Food and Drug Administration (FDA) for aiding in the pre-surgical evaluation of a woman’s ovarian mass for cancer. Vermillion, Inc. (Nasdaq: VRML), a molecular diagnostics company, developed OVA1, and Quest Diagnostics Incorporated (NYSE: DGX), the world’s leading diagnostic testing company, offers OVA1 testing services in the United States and India. Quest Diagnostics and Vermillion both participated in the study and Vermillion also helped fund the study.  Neither company had any involvement in the development of the manuscript.

Vermillion and Quest Diagnostics Sign Agreement to Make OVA1 Available in India

AUSTIN, TEXAS, APRIL 4, 2011
(NASDAQ: VRML)

Vermillion, a molecular diagnostics company, today announced that it has signed an agreement with Quest Diagnostics to make OVA1 available in India. The companies are targeting a launch in the second quarter of 2011. Additionally, at the International Gynecologic Cancer Society (IGCS) regional meeting held in New DelhiApril 2-3, 2011, Dr. Fred Ueland presented data demonstrating the high sensitivity for ovarian malignancy of OVA1 in combination with ultrasound.

"We are pleased to sign this agreement to make this important new test available to women outside the United States. India represents an outstanding market opportunity where there are approximately 350 million women," said Gail S. Page, President and CEO of Vermillion, Inc. "Vermillion is now poised for growth both domestically and internationally as we continue to develop our international strategy in concert with the efforts already underway in the US."

OVA1 Included in Latest ACOG/SGO Committee Opinion

AUSTIN, TEXAS, MARCH 14, 2011
(NASDAQ: VRML)

Vermillion, a molecular diagnostics company, announced today the inclusion of OVA1® as part of the recently published ACOG/SGO committee opinion. In the March edition of Obstetrics and Gynecology, the American College of Obstetricians and Gynecologists (ACOG) and Society of Gynecologic Oncologists (SGO) published an update committee opinion on the role of the obstetrician-gynecologist in the early detection of epithelial ovarian cancer.(1) This updates the original opinion, which was published in 2002.

Significantly, the updated ACOG/SGO opinion cites the FDA clearance of OVA1 and indicates that OVA1 "appears to improve the predictability of ovarian cancer in women with pelvic masses." Although OVA1 is not intended to be a screening test, it "may be useful for evaluating women with a pelvic mass."